Replenix Hyaluronic Acid Hydration Serum

Serums & Treatments • Serum • 1 fl oz

$95

25% Off with code MDW25

EARN +950 POINTS WHEN PURCHASING THIS PRODUCT

Product Benefits

Delivers deep, long-lasting moisture with multi-molecular hyaluronic acid
Visibly reduces the appearance of fine lines and promotes a supple, youthful texture
Supports the skin barrier and reduces redness or irritation with gentle, antioxidant-rich ingredients

Expert Review

Enhances radiance and leaves the skin looking fresh, dewy, and revitalized.

Product variants

In stock & ships same day! *

Free Shipping for US Orders

Free Returns No questions Asked

Earn rewards with our Loyalty Program

Authenticity Guaranteed

All products at DermStreet are authentic guaranteed. Trusted by thousands, we’ve earned over 1,600+ 5 star reviews.

The Replenix Hyaluronic Acid Hydration Serum is a dermatologist-developed, ultra-hydrating formula designed to deliver intense moisture and plumpness to all skin types. Powered by medical-grade, multi-molecular hyaluronic acid, this lightweight serum penetrates deeply to replenish hydration at multiple layers of the skin while visibly smoothing fine lines and improving elasticity. Enriched with antioxidants and soothing ingredients, it calms and protects the skin barrier, leaving your complexion soft, supple, and radiant. Fast-absorbing and non-comedogenic, it layers seamlessly under moisturizers and makeup for all-day hydration and a fresh, dewy glow.

All Skin Types

Purified Water, Glycerin, Sodium PCA, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Camellia Sinensis (White Tea) Extract, Palmitoyl Tripeptide-28, Erothioneine, Glutathione, Zinc PCA, Copper PCA, Phenoxyethanol, Disodium EDTA

To apply Replenix Hyaluronic Acid Hydration Serum, use on clean, slightly damp skin by dispensing 1–2 pumps and gently pressing it into the face and neck—follow with your moisturizer to lock in hydration; use twice daily, morning and evening, for a plump, smooth, and radiant complexion.

All Orders Are Shipped Same Day

Free U.S. Shipping Orders Over$50 View Our Shipping Policy

Return Policy: View Our Return Policy

How Can We Help?

Do you have any questions, concerns, or need assistance choosing a product? We're here to help!

Shop Replenix

25% Off with code MDW25

The Replenix Tinted Brightening Eye Cream is a dermatologist-developed, all-in-one eye treatment that instantly brightens, hydrates, and revitalizes the delicate under-eye area. Infused with medical-grade ingredients including antioxidant-rich Green Tea...

best seller

4.5

(22 reviews)

Replenix Tinted Brightening Eye Cream

Regular price $61

Same day shipping*
25% Off with code MDW25

Introducing Replenix Age Restore Nighttime Therapy, a luxurious nighttime treatment designed to rejuvenate and replenish your skin while you sleep. Formulated with a potent blend of antioxidants, peptides, and hydrating...

staff pick

4.43

(21 reviews)

Replenix Age Restore Nighttime Therapy

Regular price $98

Same day shipping*
25% Off with code MDW25

The Replenix Gly-Sal 10-2 Clarifying Pads are maximum-strength, dermatologist-developed treatment pads formulated with 10% glycolic acid and 2% salicylic acid to powerfully exfoliate, clear pores, and target stubborn acne. These...

Quick Shop

#1 Trending

4.69

(16 reviews)

Replenix Gly-Sal 10-2 Clarifying Pads

Regular price $36.50

Same day shipping*

Quick Shop
25% Off with code MDW25

The Replenix Green Tea Gentle Soothing Cleanser is a dermatologist-developed, antioxidant-rich facial cleanser that gently removes impurities, excess oil, and makeup without stripping or irritating the skin. Infused with calming,...

Quick Shop

staff pick

4.61

(18 reviews)

Replenix Green Tea Gentle Soothing Cleanser

Regular price $39.50

Same day shipping*

Quick Shop
25% Off with code MDW25

The Replenix Glycolic Acid 20% Resurfacing Cream is a high-potency, dermatologist-developed treatment designed to deeply exfoliate, smooth, and renew the skin’s texture. Powered by a concentrated 20% glycolic acid formula,...

Quick Shop

4.64

(11 reviews)

Replenix Glycolic Acid 20% Resurfacing Cream

Regular price $47

Same day shipping*

Quick Shop
25% Off with code MDW25

The Replenix Glycolic Acid 20% Resurfacing Peel is a powerful, dermatologist-developed at-home treatment designed to deliver professional-grade exfoliation and skin renewal. Formulated with a high-strength 20% glycolic acid concentration, this...

4.83

(12 reviews)

Replenix Glycolic Acid 20% Resurfacing Peel

Regular price $36.50

Same day shipping*
25% Off with code MDW25

The Replenix Hydrating Antioxidant Sunscreen SPF 50+ is a dermatologist-developed, broad-spectrum sunscreen that delivers powerful UVA/UVB protection while deeply hydrating and nourishing the skin. Formulated with medical-grade antioxidants including Green...

Quick Shop

4.58

(12 reviews)

Replenix Hydrating Antioxidant Sunscreen SPF 50+

Regular price $49

Same day shipping*

Quick Shop
25% Off with code MDW25

The Replenix Retinol Smooth + Tighten Body Lotion is a powerful, dermatologist-developed body treatment designed to visibly firm, smooth, and rejuvenate skin from the neck down. Infused with clinical-grade retinol...

4.7

(10 reviews)

Replenix Retinol Smooth + Tighten Body Lotion

Regular price $94

Same day shipping*

Shop Replenix

I loooove this serum!!! My skin feels plump and refreshed instantly.

Lightweight and super effective this is now my go-to hyaluronic acid serum. It absorbs quickly and leaves my skin feeling dewy but not sticky.

I’ve tried several HA serums, and this one is by far my favorite. It’s gentle, fast-absorbing, and keeps my skin hydrated all day. I layer it under my moisturizer and my makeup goes on smoother than ever. No irritation, no residue just soft, glowing skin!

This ia a perfect daily hydrating boost for my skin!

I have dry, flaky skin and this serum has helped tremendously. It calms my skin instantly and gives me a soft, healthy glow. Bonus: it layers great with other products.